SALICYLIC ACID ISOPROPYL ESTER
isopropyl salicylate
CAS: 607-85-2
Molecular Formula: C10H12O3
SALICYLIC ACID ISOPROPYL ESTER - Names and Identifiers
| Name | isopropyl salicylate |
| Synonyms | isopropyl salicylate Isopropyl salicylate ISOPROPYL 2-HYDROXYBENZOATE propan-2-yl 2-hydroxybenzoate Propan-2-yl 2-hydroxybenzoate SALICYLIC ACID ISOPROPYL ESTER Salicylic Acid Isopropyl Ester 2-HYDROXYBENZOIC ACID ISOPROPYL ESTER o-Hydroxybenzoic acid isopropyl ester 2-hydroxybenzoic acid 1-methylethyl ester 2-Hydroxybenzoic acid 1-methylethyl ester |
| CAS | 607-85-2 |
| EINECS | 210-143-2 |
| InChI | InChI=1/C10H12O3/c1-7(2)13-10(12)8-5-3-4-6-9(8)11/h3-7,11H,1-2H3 |
SALICYLIC ACID ISOPROPYL ESTER - Physico-chemical Properties
| Molecular Formula | C10H12O3 |
| Molar Mass | 180.2 |
| Density | 1.06 |
| Melting Point | 73-75 °C(lit.) |
| Boling Point | 122 °C (18 mmHg) |
| Flash Point | 122°C/18mm |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 0.0237mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to very slightly yellow |
| pKa | 8.37±0.30(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.509-1.511 |
SALICYLIC ACID ISOPROPYL ESTER - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| TSCA | Yes |
| HS Code | 29182300 |
SALICYLIC ACID ISOPROPYL ESTER - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | isopropyl salicylate, also known as isopropyl O-hydroxybenzoate, is an important organic chemical raw materials and pharmaceutical intermediates, can be used as a solvent, catalysts, plastic additives and pharmaceutical and other. used as pesticide intermediate |
| preparation | 1) preparation of solid acid catalyst: the preparation method of solid acid has been mature, the specific method is as follows: 13.4 gFeCl3.6H2O(0.05mol) was dissolved in ml water, and then 5mol/L ammonia solution was added under stirring to produce Fe(OH)3 precipitate, which was slightly alkaline. After filtration, the precipitate was washed with hot water. After suction drying, the solid acid was obtained by soaking in 40ml of 2mol/L sulfuric acid for 1.5h and drying at 110 ° C. Finally, the precipitate was calcined in a muffle furnace at 600 ° C. For 3h. 2) synthesis, separation and purification of isopropyl salicylate: 6.9g(0.05mol) of salicylic acid and 15ml(0.2mol) of isopropyl alcohol were added to the reaction kettle, heating reflux and maintain reflux temperature of 105~110 ℃, set the reaction time, after the reaction is cooled, vacuum suction filtration to remove unreacted salicylic acid and excess catalyst, then it was washed with saturated NaHCO3 solution until no bubbles were generated. The supernatant was taken and dried with anhydrous MgSO4 to obtain crude ester. The crude ester was added to the distillation flask for vacuum distillation, and the 65~68 °c fraction was collected as the refined ester. |
Last Update：2024-04-09 15:16:51
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